Non‐steroidal anti‐inflammatory drugs, polygenic risk score and colorectal cancer risk
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چکیده
منابع مشابه
Use of nonsteroidal antiinflammatory drugs and risk of endometrial cancer.
Results of 3 previous studies suggest that use of aspirin is related to a reduced risk of endometrial cancer, at least in obese women (body mass index, > or =30 kg/m(2)). Using data obtained in a population-based, case-control study in western Washington State, the authors examined this question. Between 2003 and 2005, 410 women diagnosed with invasive endometrial cancer and 356 controls were i...
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BACKGROUND Nonsteroidal antiinflammatory drugs (NSAIDs) inhibit the development of lung tumors in experimental animals. To the authors' knowledge there are little data regarding whether regular use of NSAIDs reduces the risk of developing lung carcinoma in humans. METHODS The association between lung carcinoma risk and regular use of NSAIDs, including aspirin, was evaluated in a hospital-base...
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Nonsteroidal antiinflammatory drugs (NSAIDs) may play a role in breast cancer prevention; however, breast cancer subtypes and lifestyle/host factors may influence their impact. During 1996-1998 in Canada, the authors examined the association between regular NSAID use (defined as daily use for at least 2 months) and breast cancer risk by estrogen receptor (ER) and progesterone receptor (PR) stat...
متن کاملUse of nonsteroidal antiinflammatory drugs and risk of breast cancer: the Case-Control Surveillance Study revisited.
Several studies have suggested that use of nonsteroidal antiinflammatory drugs (NSAIDs) may reduce the risk of breast cancer. Reductions in risk may vary according to the hormone receptor status of the tumor or the type of NSAID used. The authors extended a previous US hospital-based case-control study (the Case-Control Surveillance Study) to include 444 additional cases, for a total of 7,006 i...
متن کاملPRSice: Polygenic Risk Score software
SUMMARY A polygenic risk score (PRS) is a sum of trait-associated alleles across many genetic loci, typically weighted by effect sizes estimated from a genome-wide association study. The application of PRS has grown in recent years as their utility for detecting shared genetic aetiology among traits has become appreciated; PRS can also be used to establish the presence of a genetic signal in un...
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ژورنال
عنوان ژورنال: Alimentary Pharmacology & Therapeutics
سال: 2021
ISSN: 0269-2813,1365-2036
DOI: 10.1111/apt.16438